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Apexbio Technology LLC BMS-708163 (Avagacestat) 1146699-66-2 50mg
Supplier: Apexbio Technology LLC A402250
BMS-708163 (Avagacestat CAS 1146699-66-2) is an orally bioavailable small-molecule inhibitor selectively targeting -secretase an enzyme responsible for amyloid precursor protein (APP) cleavage into neurotoxic amyloid-beta (A ) species associated with Alzheimer s disease pathology It demonstrates potent inhibitory activity (IC50 0 3 nM) effectively reducing A 40 and A 42 production in vitro in H4-8Sw cells Relative selectivity testing indicates a substantially lower inhibitory effect (approximately 190-fold weaker) toward Notch signaling compared to APP processing In animal models oral administration significantly reduces A levels in plasma cerebrospinal fluid and brain tissues underpinning its application in Alzheimer s disease research
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