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Apexbio Technology LLC BMS-790052 dihydrochloride,5mg CAS# 1009119-65-6
Supplier: Apexbio Technology LLC A32575
BMS-790052 is a potent inhibitor of HCV NS5A with EC50 value of 9-50 pM [1].NS5A (nonstructural protein 5A) is a zinc-binding protein and plays a pivotal role in HCV RNA replication. NS5A involves in mediating the host cell function and HCV infection, therefore, it is regarded as a promising target for HCV treatment [2]. BMS-790052 is a selective HCV NS5A inhibitor and has the most potent ability to inhibit HCV replication reported so far. When using FRET assays to determine the efficiay of BMS-790052 on HCV NS5A, replicon cells were cultured in 96-well plates and after 12 hours BMS-790052 was added to test the replication activity and cytotoxicity, the results showed that the mean values of BMS-790052 for genotype 1a and 1b were 50 and 9 pM, respectively [1]. Other sizes are also available. Please inqury us for quote.
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