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Apexbio Technology LLC BMS-927711(Synonyms: Rimegepant, Nurtec ODT, BMS927711, BMS 927711, BHV-3000, BHV3000), 25mg, CAS: 1289023-67-1.
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Catalog No. 5000060334
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BMS-927711 (CAS 1289023-67-1) is an orally bioavailable antagonist targeting the calcitonin gene-related peptide (CGRP) receptor CGRP acts through a G-protein coupled receptor composed of calcitonin receptor-like receptor (CLR) receptor activity-modifying protein 1 (RAMP1) and receptor component protein (RCP) Research shows that CGRP levels are elevated during migraine episodes suggesting a role in migraine pathogenesis In binding assays using SK-N-MC cell membranes expressing endogenous human CGRP receptors BMS-927711 exhibited potent CGRP receptor antagonism (IC50 0 14 nM) Clinical studies have demonstrated its potential application in the acute treatment of migraine

Catalog No. 50-000-60334 Supplier Apexbio Technology LLC Supplier No. A325925
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BMS-927711 (CAS 1289023-67-1) is an orally bioavailable antagonist targeting the calcitonin gene-related peptide (CGRP) receptor CGRP acts through a G-protein coupled receptor composed of calcitonin receptor-like receptor (CLR) receptor activity-modifying protein 1 (RAMP1) and receptor component protein (RCP) Research shows that CGRP levels are elevated during migraine episodes suggesting a role in migraine pathogenesis In binding assays using SK-N-MC cell membranes expressing endogenous human CGRP receptors BMS-927711 exhibited potent CGRP receptor antagonism (IC50 0 14 nM) Clinical studies have demonstrated its potential application in the acute treatment of migraine

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