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Medchemexpress LLC BMS-986235 (LAR-1219) | 2253947-47-4 | 99.7% | 500 MG
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Catalog No. 5000339827
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BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure.

  • It inhibits neutrophil chemotaxis and stimulates macrophage phagocytosis, key endpoints to promote resolution of inflammation.
  • It can attenuate left ventricle and global cardiac remodeling after left anterior descending (LAD) in mice (0.3 mg/kg; p.o.; daily for 24 days).
  • Treatment shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours, 120 nmol/L·h, and 24%, respectively (1 mg/kg; p.o.).

Catalog No. 50-003-39827 Supplier Medchemexpress LLC Supplier No. HY131180500MG
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BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure.

  • It inhibits neutrophil chemotaxis and stimulates macrophage phagocytosis, key endpoints to promote resolution of inflammation.
  • It can attenuate left ventricle and global cardiac remodeling after left anterior descending (LAD) in mice (0.3 mg/kg; p.o.; daily for 24 days).
  • Treatment shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours, 120 nmol/L·h, and 24%, respectively (1 mg/kg; p.o.).

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