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Cayman Chemical Bn ORL 24hydrochlorIde 10mg
Supplier: Cayman Chemical 2948510 MG
A NOP receptor antagonist (Ki = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor); selective for NOP receptors over μ-, δ-, and κ-opioid receptors (Kis = 0.19, 0.34, and >1 µM, respectively); reduces NOP-induced GTPγS binding (pA2 = 9.98) and calcium mobilization (KB = 0.93 nM) in CHO cells; inhibits electrically induced twitches in isolated mouse and rat vas deferens, as well as isolated guinea pig ileum, at 100 nM; reverses BPR1M97-induced thermal and mechanical antinociceptive activities in mice
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