Medchemexpress LLC BNC375 | 1557240-80-8 | 99.6% | 10 MG

Supplier:  Medchemexpress LLC HY12857510MG

BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. It exhibits good CNS-agent like properties and clinical candidate potential. BNC375 significantly potentiates the acetylcholine signal without changing the rapid receptor desensitization. In vivo, BNC375 (0.003-10.0 mg/kg, administered orally) exhibits a Minimum Effective Dose (MED) of 0.03 mg/kg, achieving full reversal of scopolamine-induced impairment at 1.0 mg/kg in a mouse T-maze model. It has a plasma half-life (t1/2) of 1.2 hours.

• Potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs.
• Exhibits good CNS-agent like properties.
• Clinical candidate potential.
• Significantly potentiates acetylcholine signal.
• Achieves full reversal of scopolamine-induced impairment in mouse T-maze model.
• Plasma half-life (t1/2) of 1.2 hours.

Catalog No. 50-003-38279