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Medchemexpress LLC BNC375 | 1557240-80-8 | 99.6% | 50 MG
Supplier: Medchemexpress LLC HY12857550MG
BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs, exhibiting an EC50 of 1.9 μM. It possesses good CNS-agent like properties and has clinical candidate potential. It significantly potentiates the acetylcholine signal without altering rapid receptor desensitization.
- Potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs.
- Exhibits good CNS-agent-like properties.
- Has clinical candidate potential.
- Significantly potentiates the acetylcholine signal.
- Achieves full reversal of scopolamine-induced impairment at 1.0 mg/kg in a mouse T-maze model.
- Minimum effective dose (MED) of 0.03 mg/kg.
- Plasma half-life (t1/2) of 1.2 hours.
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