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Medchemexpress LLC Bobcat339 hydrochloride | 2436747-44-1 | 99.6% | 334.20 | 1 ML
Supplier: Medchemexpress LLC HY111558A10MM/1ML
Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of the TET enzyme, with IC50 values of 33 μM for TET1 and 73 μM for TET2. It is valuable in the field of epigenetics and serves as a foundation for developing new therapeutics targeting DNA methylation and gene transcription.
- Potent and selective cytosine-based inhibitor of TET enzyme.
- Useful in epigenetics research.
- Serves as a starting point for new therapeutics targeting DNA methylation and gene transcription.
- Inhibitory activity is directly related to Cu(II) content; the Bobcat339-copper mixture shows significantly higher TET inhibition than either alone.
- Significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells at 10 μM for 24 hours.
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