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Sigma Aldrich Boca1V2Pf1-Nhc6-Nh2

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91-796-650MG 1 g
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Protein degrader building block BocA1V2PF1-NHC6-NH2 enables the synthesis of molecules for targeted protein degradation and SNIPER (specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers) technology. Developed in partnership with ComInnex, this conjugate contains an in silico-derived IAP-recruiting ligand, an alkyl-chain crosslinker, and a pendant amine for reactivity with an acid on a target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and protein degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, including CRBN and VHL targeted, parallel synthesis can be used to more quickly generate SNIPER and PROTAC™ degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight.Building blocks in this series:916978 BocA1V2PF1917966 BocA1V2PF1-NHC6-NH2916706 BocA1V2PF1-NHC10-NH2916951 BocA1V2PF1-NHPEG1-NH2917214 BocA1V2PF1-NHPEG3-NH2Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived LigandsIn Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)SNIPERs-Hijacking IAP activity to induce protein degradationE3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New OnesPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

CAS 10352-14-4
Molecular Formula C13H7Br2NO
Linear Formula C13H7Br2NO
MDL Number MFCD00224046
Quantity 1 g
Molecular Weight (g/mol) 353.01 g/mol
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