Medchemexpress LLC Bomedemstat dihydrochloride | 99.6% | 592.54 | 50 MG

Supplier:  Medchemexpress LLC HY109169C50MG

Bomedemstat dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. It increases H3K4 and H3K9 methylation to alter gene expression, showing anti-cancer activities by inhibiting cancer cell proliferation and inducing apoptosis.

• Orally active.
• Irreversible LSD1 inhibitor.
• Increases H3K4 and H3K9 methylation.
• Alters gene expression.
• Exhibits anti-cancer activities.
• Inhibits cancer cell proliferation.
• Induces apoptosis.
• Selectively inhibits proliferation and induces apoptosis of Jak2V617F cells.
• Enhances cell survival and induces apoptosis via BCL-XL and PUMA.
• Leads to cell cycle arrest.
• Normalizes or improves blood cell counts in animal models.
• Reduces spleen volumes in animal models.
• Restores normal splenic architecture.
• Reduces bone marrow fibrosis in animal models.

Catalog No. 50-003-44512