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AdipoGen Borrelidin
SDP

Supplier:  AdipoGen BVT0098C500

Encompass_Preferred

Chemical. CAS 7184-60-3. Formula C28H43NO6. MW 489.6. Isolated from Streptomyces sp. Macrolide antibiotic. Bacterial, protozoan and mammalian threonyl-tRNA synthetase THrRS inhibitor. Antiangiogenic IC50 = 0.8 nM and anticancer agent. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of B16-BL6 melanoma cells. Cyclin-dependent kinase CDK inhibitor. Antiviral. Potent antimalarial agent IC50 = 0.97 nM. Inhibitor of potato scab disease.

Catalog No. 50-256-2101


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