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Borrelidin, Tocris Bioscience™

Catalog No. 47061
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Quantity:
1 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Antiangiogenic; inhibits threonyl-tRNA synthetase

Antibiotic and antiangiogenic. Selectively inhibits threonyl-tRNA synthetase (ThrRS). Exhibits antiangiogenic activity in a mouse model of tumor angiogenesis. Induces apoptosis in capillary tube-forming endothelial cells; disrupts capillary tubes and inhibits their formation (IC50 = 0.8 nM in rat aorta). Induces the unfolded protein response (UPR) and apoptosis in oral cancer cells.

Chemical Identifiers

CAS 7184-60-3
Molecular Formula C28H43NO6
Molecular Weight (g/mol) 489.653
InChI Key OJCKRNPLOZHAOU-MJQQLCDASA-N
Synonym treponemycin
PubChem CID 133655849
IUPAC Name (1S,2S)-2-[(2R,4Z,6E,8S,9R,13R,15R,16R)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid
SMILES CC1CC(CC(C(C(=CC=CCC(OC(=O)CC(C(C1)C)O)C2CCCC2C(=O)O)C#N)O)C)C

Specifications

Quantity 1 mg
Formula Weight 489.64
Percent Purity >98%
Chemical Name or Material Borrelidin

Safety and Handling

Recommended Storage Store at -20°C
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