Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Bortezomib, 98%

Catalog No. AAJ60378MA
Click to view available options
Quantity:
10 mg
25 mg

Bortezomib (CAS # 179324-69-7) is an inhibitor of protein degradation pathways. | CAS: 179324-69-7 | C19H25BN4O4 | 384.243 g/mol

A potent, highly selective and reversible inhibitor of the 20S proteasome, Bortezomib is used as an antineoplastic agent, which controls the growth of cancer cells. It is also useful in the treatment of multiple myeloma.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Bortezomib is an antineoplastic compound derived from boronic acid
• Bortezomib reversibly inhibits the 26S proteostome that maintains cell cycle pathways related to growth and division
• Bortezomib is an inhibitor of NF-κB, a factor that is constituitively active in some cancers

Application

• Bortezomib is suitable for use in the research of multiple myeloma and lymphomas, and for use in the research of protein degradation pathways
• Bortezomib is intended for in vitro and biochemical applications

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 179324-69-7
Molecular Formula C19H25BN4O4
Molecular Weight (g/mol) 384.243
MDL Number MFCD09056737
InChI Key GXJABQQUPOEUTA-RDJZCZTQSA-N
Synonym bortezomib, velcade, bortezomib ps-341, dpba, pyz-phe-boroleu, unii-69g8bd63pp, velcade tn, bortezomib velcade, 1r-3-methyl-1-2s-1-oxo-3-phenyl-2-pyrazinylcarbonyl amino propyl amino butyl boronic acid, 1r-3-methyl-1-2s-3-phenyl-2-pyrazine-2-carbonylamino propanoyl amino butyl boronic acid
PubChem CID 387447
ChEBI CHEBI:52717
IUPAC Name [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
SMILES B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

Specifications

Melting Point 139°C to 143°C
Color Brown to White
Quantity 10 mg
UN Number UN3249
Merck Index 14,1351
Solubility Information Soluble in chloroform,dimethyl sulfoxide,ethanol and methanol.
Formula Weight 384.24
Percent Purity 99%
Physical Form Powder
Chemical Name or Material Bortezomib
Hazard Category H301+H311-H330-H372
Hazard Statement GHS H Statement
H300-H310-H330-H372
Fatal if swallowed.
Fatal in contact with skin.
Fatal if inhaled.
Causes damage to organs through prolonged or repeated exposure.
Precautionary Statement P260-P264b-P270-P271-P280-P284-P301+P310-P302+P352-P304+P340-P310-P312-P314-P330-P361-P363-P501c
DOTInformation Transport Hazard Class: 6.1; Packing Group: II; Proper Shipping Name: MEDICINE, SOLID, TOXIC, N.O.S.
RTECSNumber ED7771666
TSCA No
Recommended Storage Store at -20°C

RUO – Research Use Only

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.