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Cayman Chemical Borusertb 10mg
Supplier: Cayman Chemical 3338710 MG
An Akt1 and Akt2 inhibitor (Kis = 2 and 6 nM, respectively); selective for Akt1 and Akt2 over Akt3 (Ki = 91 nM); reduces viability in Ba/F3 cells expressing human Akt1 or Akt2 but not Ba/F3 cells expressing human Akt3 at 5 µM; decreases the levels of phosphorylated Akt1, Akt2, PRAS40, and ribosomal protein S6 in PANC-1 cancer cells at concentrations of 0.3 to 5 µM; prevents tumor growth in combination with trametinib in three PDX mouse models of K-Ras-mutant colorectal cancer at 20 mg/kg per day
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