Apexbio Technology LLC Bosentan Hydrate 157212-55-0 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B15215.1

Bosentan Hydrate (CAS 157212-55-0) is a sulfonamide-derived competitive antagonist of endothelin receptors exhibiting preferential affinity toward endothelin A over endothelin B receptors By interfering with endothelin-triggered signaling in endothelial and vascular smooth muscle cells it attenuates vasoconstrictive and bronchoconstrictive responses In vitro studies revealed bosentan inhibited endothelin receptor activity in P388/dx cells (IC50 15 1 1 6 M) and effectively reversed antiangiogenic effects of systemic sclerosis patient sera on dermal microvascular endothelial cells In animal models bosentan administration post-myocardial infarction significantly elevated plasma leptin levels Clinically bosentan is applied extensively in research on pulmonary arterial hypertension showing beneficial outcomes on patients exercise capacity

Catalog No. 50-000-63770