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Apexbio Technology LLC Bosutinib (SKI-606)(Synonyms: SKI-606, Bosulif, SKI606, Bosutinib monohydrate), 10mM (in 1mL DMSO), CAS: 380843-75-4.
Supplier: Apexbio Technology LLC A21495.1
Bosutinib (SKI-606 CAS 380843-75-4) is a dual inhibitor targeting c-Src and Abl kinases with IC50 values of approximately 1 2 nM and 1 nM respectively It suppresses phosphorylation of Bcr-Abl Src and Stat5 in chronic myeloid leukemia (CML) cells thereby decreasing proliferation and inducing regression in K562 xenograft tumor models Bosutinib also reduces Src autophosphorylation and inhibits -catenin signaling by blocking its interaction with TCF4 transcription factor consequently downregulating cyclin D1 expression in colorectal cancer cells This mechanism results in decreased cell motility and enhanced -catenin binding to E-cadherin highlighting utility in cancer research
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