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Medchemexpress LLC Bpam344 | 1204572-55-3 | 99.7% | 10 MG
SDP

Supplier:  Medchemexpress LLC HY12908610MG

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BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM). It functions by potentiating glutamate-evoked currents and significantly decreasing desensitization kinetics.

  • Potentiates glutamate-evoked currents of GluK2a 21-fold at 200 μM, with an EC50 of 79 μM
  • Significantly decreases desensitization kinetics
  • Potentiates peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), and AMPA receptor subunit GluA1i (5-fold)

Catalog No. 50-003-39608


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