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Medchemexpress LLC BPAM344 | 1204572-55-3 | 99.7% | 50 MG
Supplier: Medchemexpress LLC HY12908650MG
BPAM344 is a positive allosteric modulator (PAM) of kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a. It is intended for research use only and not for sale to patients.
- Potentiates glutamate-evoked currents of GluK2a 21-fold at 200 μM
- Significantly decreases desensitization kinetics
- Potentiates peak current amplitude of KAR subunits GluK3a, GluK2a, and GluK1b
- Potentiates AMPA receptor subunit GluA1i
- Exhibits EC50 of 0.9 μM for positive allosteric modulation of AMPA receptor in primary neuronal culture
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