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Medchemexpress LLC BPK-25 | 2305052-86-0 | 99.9% | C21H17ClN4O2 | 50 MG
Supplier: Medchemexpress LLC HY14155050MG
BPK-25 is an active acrylamide that promotes the degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins through a post-translational mechanism involving covalent protein engagement. It also inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP.
- Promotes degradation of NuRD complex proteins.
- Inhibits TMEM173 activation.
- Suppresses activation of NF-κB.
- Blocks nuclear factor of activated T-cells (NFAT) activation.
- Reduces NFATc2 expression in T cells.
- Striking and selective reduction of several proteins in the NuRD complex in a concentration- and time-dependent manner.
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