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Medchemexpress LLC BPO-27 racemate | 1314873-02-3 | 98.5% | 548.34 | 1 ML
Supplier: Medchemexpress LLC HY19778A10MM/1ML
BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. This compound is an analogue of PPQ-102.
- Potent CFTR inhibitor with an IC50 of 8 nM.
- R enantiomer inhibits CFTR chloride conductance with an IC50 of 4 nM.
- Both enantiomers show metabolic stability in hepatic microsomes.
- R-BPO-27 binds near the canonical ATP binding site.
- Provides sustained therapeutic concentrations in the kidney in vivo.
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