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Apexbio Technology LLC BPTES 314045-39-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B60085.1
BPTES (CAS 314045-39-1) is a selective inhibitor of kidney-type glutaminase (GLS) an enzyme responsible for converting glutamine to glutamate and ammonia It exhibits inhibitory activity against GLS with a reported Ki of approximately 3 M GLS-mediated glutamine metabolism is particularly essential in proliferating and malignant cells BPTES reduces glutamine-to-glutamate conversion in tumor cells diminishing the transamination of pyruvate to alanine as observed in decreased alanine-to-pyruvate ratios in animal models In vitro BPTES inhibits growth by approximately 50% of IDH1-mutant AML cells at 20 M concentration but does not significantly affect wild-type AML cells highlighting its relevance for cancer metabolism research
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