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Medchemexpress LLC BPTES | 314045-39-1 | 98.0% | 200 MG
Supplier: Medchemexpress LLC HY12683200MG
BPTES is an allosteric and selective glutaminase inhibitor with an IC50 of 0.16 μM. It is for research use only.
- Inhibits glutaminase activity
- Diminishes glutamate and α-KG levels
- Increases glycolytic intermediates
- Inhibits PDAC cell proliferation
- Slows growth of mutant IDH1 cells
- Shows synergistic anti-cancer effect with 5-FU in A549 and EKVX cell lines
- Reduces growth in most NSCLC cell lines
- Reduces levels of TCA cycle metabolites
- Reduces ATP production
- Attenuates tumor growth in patient-derived pancreatic orthotopic tumor models
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