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Medchemexpress LLC BPU17 | 2198977-68-1 | 98.2% | 252.70 | 250 MG
Supplier: Medchemexpress LLC 250MGHY162904
BPU17 binds to PHB1, causing mild defects in mitochondrial function through impaired PHB1-PHB2 interaction. This inhibits SRF/CArG-box-dependent transcription, suppressing the epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs). BPU17 also shows antifibrotic activity in vivo and is promising for research into anti-neovascular age-related macular degeneration (nAMD) agents.
- EMT inhibitor
- PHB1 activator
- Antifibrotic activity in vivo
- Promising for research of anti-neovascular age-related macular degeneration (nAMD) agent
- Solid, white to off-white appearance
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