Enzo Life Sciences BQCA (50mg). CAS: 338747-41-4

Supplier:  Enzo Life Sciences BMLC1210050

Highly selective allosteric potentiator of the M1 muscarinic acetylcholine receptor (mAChR). Reduces the concentration of ACh required to activate M1 up to 129-fold and displays no potentiation, agonism or antagonism activity at other mAChRs at concentrations up to 100µM. Reverses scopolamine-induced memory deficits and increases blood flow to the cerebral cortex in mouse models. M1 activators slow the progression of Alzheimers disease. Induces β-arrestin recruitment to M1. At 100µM, it activated M1 in the absence of ACh to ca. 50% maximal response. At 10µM, it reduced the concentration of ACh required to displace radioligand by 45-fold. In vivo experiments were carried out in mice at 15 or 20mg/kg. The compound is cell permeable, brain penetrant and orally active. Alternative name: 1-(4-Methoxybenzyl)-4-oxo-1,4-dihydro-3-quinoline carboxylic acid, Benzyl quinolone carboxylic acid. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO (10mg/ml). Long Term Storage: Ambient.

Catalog No. 50-201-0348