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Medchemexpress LLC Bragsin2 | 342795-08-8 | 99.9% | 289.16 | 1 ML
Supplier: Medchemexpress LLC HY11155050MG
Bragsin2 is a potent, selective, and noncompetitive inhibitor of the nucleotide exchange factor BRAG2. It functions by binding at the interface between the PH domain of BRAG2 and the lipid bilayer, which prevents BRAG2 from activating lipidated Arf GTPase. Bragsin2 has been shown to affect breast cancer stem cells.
- Potent, selective, and noncompetitive BRAG2 inhibitor
- Binds at the interface between the PH domain of BRAG2 and the lipid bilayer
- Prevents BRAG2 from activating lipidated Arf GTPase
- Affects breast cancer stem cells
- Inhibits Arf GTPase activation in HeLa cells at 50 μM
- Inhibits growth of SUM149 and S68 cells at 50 μM
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