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Avanti Polar Lipids L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt), 383907-42-4, MFCD28901390, 10 mg

Supplier:  Avanti Polar Lipids 840046X10MG

Encompass

Formula Weight: 1096.385, Purity >99%, Stability: 3 Months, Storage Temperature: -20°C. Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.

Catalog No. NC0998838


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