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Medchemexpress LLC Branaplam | 1562338-42-4 | 98.90% | 393.48 | 200 MG
SDP

Supplier:  Medchemexpress LLC HY19620200MG

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Branaplam is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. It inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.

  • Highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator.
  • Elevates full-length SMN protein.
  • Extends survival in a severe spinal muscular atrophy (SMA) mouse model.
  • EC50 of 20 nM for SMN.
  • IC50 of 6.3 μM for hERG.

Catalog No. 50-004-00794


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