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Medchemexpress LLC Branaplam hydrochloride | 1562338-39-9 | 99.4% | 429.94 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY19620A100MG

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Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective, and orally active survival motor neuron-2 (SMN2) splicing modulator. It has an EC50 of 20 nM for SMN and inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. This compound is capable of elevating full-length SMN protein and has been shown to extend survival in a severe spinal muscular atrophy (SMA) mouse model.

  • Highly potent, selective, and orally active
  • SMN2 splicing modulator
  • Elevates full-length SMN protein
  • Extends survival in a severe spinal muscular atrophy (SMA) mouse model
  • Inhibits hERG with an IC50 of 6.3 μM

Catalog No. 50-004-01953


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