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Medchemexpress LLC Brd0539 | 1403838-79-8 | MFCD32709969 | 98.3% | 452.54 | 50 MG
SDP

Catalog No. 5000349423
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BRD0539 is an inhibitor of *Streptococcus pyogenes* Cas9 (SpCas9) with an IC50 of 22 μM in an *in vitro* DNA cleavage assay. It dose-dependently blocks the formation of the DNA-bound state and impairs perturbation induced by 4PAM DNA.

  • Does not interfere with SpCas9:gRNA interaction
  • Inhibits SpCas9 in eGFP-disruption assay
  • Cannot inhibit FnCpf1

Catalog No. 50-003-49423 Supplier Medchemexpress LLC Supplier No. HY13625150MG
May include imposed supplier surcharges.
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BRD0539 is an inhibitor of *Streptococcus pyogenes* Cas9 (SpCas9) with an IC50 of 22 μM in an *in vitro* DNA cleavage assay. It dose-dependently blocks the formation of the DNA-bound state and impairs perturbation induced by 4PAM DNA.

  • Does not interfere with SpCas9:gRNA interaction
  • Inhibits SpCas9 in eGFP-disruption assay
  • Cannot inhibit FnCpf1

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