Cayman Chemical BRD4 bromodomaIn 1 TRFRET384

Supplier:  Cayman Chemical 600520384 WELL

A Dyrk1a and Gsk3B inhibitor (IC50s 6 and 16 nM respectively for the mouse enzymes) selective for Dyrk1a and Gsk3B over a panel of 57 kinases but does inhibit 10 other kinases at 1 UM increases the proliferation of R7T1 mouse pancreatic B-cells and primary human pancreatic B-cells (EC50s 0.66 and 0.54 UM respectively) increases the number of islet and B-cells and the levels of total DNA and ATP in primary human islet cells at 2 UM increases the proliferation of transplanted primary human islet cells and decreases the levels of blood glucose in mice at 50 mg/kg twice per day reduces the levels of blood glucose in an OGTT in a transgenic RIP-DTA mouse model of type I diabetes at 50 mg/kg twice per day increases the mass of and levels of insulin in pancreatic B-cells in the same mice

Catalog No. 50-289-2334