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Apexbio Technology LLC BRD4770 1374601-40-7 10mg
Supplier: Apexbio Technology LLC B483710
BRD4770 (CAS 1374601-40-7) is a small-molecule inhibitor targeting the histone methyltransferase G9a with an IC50 of 6 3 M In studies using the PANC-1 pancreatic cancer cell line BRD4770 was shown to decrease levels of di- and trimethylated histone H3 lysine 9 (H3K9) through inhibition of G9a activity This reduction in H3K9 methylation is associated with the induction of cellular senescence and cell death as well as suppression of both adherent-dependent and independent cell proliferation BRD4770 serves as a useful probe for exploring the epigenetic regulation of gene expression and cellular senescence in cancer biology research
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