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Medchemexpress LLC Brepocitinib (P-tosylate) | 2140301-96-6 | 100.0% | 561.60 | 1 ML
Supplier: Medchemexpress LLC HY112708A10MM/1ML
Brepocitinib P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor. It inhibits JAK1 with an IC50 of 17 nM and TYK2 with an IC50 of 23 nM. It also inhibits JAK2 with an IC50 of 77 nM and JAK3 with an IC50 of 6.49 μM. This compound demonstrates in vitro efficacy in inhibiting various STAT pathways and in vivo efficacy by reducing paw volume in an arthritis model.
- Potent dual inhibitor of JAK1 and TYK2
- Specific inhibition of JAK2 and JAK3 at higher concentrations
- In vitro efficacy in inhibiting STAT pathways
- In vivo efficacy in an animal model of arthritis
- Solid, white to off-white color
- Intended for research purposes only
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