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Medchemexpress LLC Brepocitinib P-Tosylate | 2140301-96-6 | 99.99% | 561.60 | 1 MG
Supplier: Medchemexpress LLC HY112708A1MG
Brepocitinib P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor. It also inhibits JAK2 and JAK3. This compound is intended for research use only.
- Potently inhibits TYK2/JAK2 mediated IL-12/pSTAT4 and IL-23/pSTAT3.
- Shows good potency against IL6/pStat1 in CD3+ cellular subset.
- Inhibits JAK1/JAK3 driven γ-common chain cytokines like IL-15/pStat5 and IL-21/pSTAT3.
- Inhibits EPO/pSTAT5 (JAK2 homodimer).
- Inhibits IL10/pSTAT3 (TYK2/JAK1) and IL27/pSTAT3 (JAK1/JAK2/TYK2).
- Significantly reduces paw volume increase in animal models of arthritis.
- Involved in clinical trials for various inflammatory and autoimmune conditions.
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