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Cayman Chemical BrIvnIb AlnInate 50mg
SDP

Supplier:  Cayman Chemical 2608150 MG

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An inhibitor of KSR-dependent MAPK signaling inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 120 nM) stabilizes KSR2 in an inactive state reduces interactions between B-RAF and KSR2-MEK1 complexes inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells at 5 M enhances the efficacy of trametinib further reducing cell viability in K-Ras mutant HCT116 and A549 cell lines but not B-RAF mutant SK-MEL-239 and A375 cell lines at 1 M

Catalog No. 50-293-3327


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