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Cayman Chemical BRL 44408maleate 5mg
Supplier: Cayman Chemical 294545 MG
An antagonist of α2A-ARs (Ki = 8.56 nM for the recombinant human receptors); >50-fold selective for α2A-ARs over α1-, α2B-, α2C-, β1-, and β2-ARs, as well as 19 other neurotransmitter receptors, transporters, and enzymes in a panel at 1 µM; inhibits forskolin-stimulated cAMP accumulation (IC50 = 92.3 nM in CHO cells expressing the recombinant human α2A-AR); increases norepinephrine and dopamine levels by 200 and 100%, respectively, in rat medial prefrontal cortex at 10 mg/kg; decreases the time rats spend immobile in the forced swim test, indicating antidepressant-like activity at 10 and 30 mg/kg; reduces para-phenylquinone-induced abdominal stretching, indicating analgesic activity, in rats at 10 and 30 mg/kg
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