Cayman Chemical BrnbrutInIb 10mg

Supplier:  Cayman Chemical 3346210 MG

A covalent BTK inhibitor (IC50 = 0.1 nM); >5,000-fold selective for BTK over a panel of 240 kinases but does inhibit TEC, BMX, and TMX (IC50s = 0.9, 1.5, and 5.0 nM, respectively); inhibits BCR stimulation-induced calcium flux in Ramos B cells (IC50 = 7.2 nM), as well as BCR stimulation-induced proliferation of, and CD86 surface expression in, peripheral B cells (IC50s = 0.04 and 0.3 nM, respectively); inhibits Fcγ receptor stimulation-induced TNF-α production in human PBMCs (IC50 = 0.3 nM); completely protective against bone destruction in a mouse model of collagen-induced arthritis at 0.5 mg/kg; reduces proteinuria and glomerular IgG immune complex deposition and increases survival in an NZB/W lupus-prone mouse model

Catalog No. 50-294-6681