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Medchemexpress LLC Broflanilide | 1207727-04-5 | 99.0% | 663.28 | 100 MG
Supplier: Medchemexpress LLC HY10868910MG
Broflanilide is an insecticide that converts into Desmethyl-Broflanilide, a powerful antagonist at the insect RDL GABA Receptor. This mechanism inhibits *S. litura* RDL GABAR with an IC50 of 1.3 nM. Desmethyl-Broflanilide shows limited activity against human GABAA α1β2γ2 receptor, mammalian GABAA α1β3γ2 receptor, and human glycine receptor (GlyR) α1β with IC50s greater than 3 μM, and less potent inhibition of GlyR α1-A288Gβ and GlyR α1-A288G (IC50s, 0.706, 0.149 μM).
- Acts as a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor.
- Inhibits *S. litura* RDL GABAR.
- Exhibits weak activity against human and mammalian GABAA receptors.
- Less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G.
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