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Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.9% | 10 MG
Supplier: Medchemexpress LLC HY12705A10MG
Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist that binds to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier.
- Potent dopamine D2/D3 receptor agonist
- Binds D2 dopamine receptor with pKi of 8.05
- Permeable to the blood-brain barrier
- Stimulates [35S]-GTPγS binding at D2 dopamine receptor expressed in CHO cells with pEC50 of 8.15±0.05
- Strong inhibitor of brain nitric oxide synthase (NOS) (IC50=10±2 μM)
- Poorly active towards inducible macrophage NOS (IC50>100 μM)
- Potent inhibitor of CYP3A4 with a calculated IC50 value of 1.69 μM
- Demonstrates significant anti-immobility action in forced swimming test (FST) and tail suspension test (TST) in mice
- Potentiates the anti-immobility action of MPE
- Decreases static mechanical allodynia (SMA) score in rats
- Induces a significant, dose-dependent decrease in pain scores in the CCI-IoN group
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