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Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.90% | 200 MG
Supplier: Medchemexpress LLC HY12705A200MG
Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, binding to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier. This compound also acts as a strong inhibitor of brain nitric oxide synthase (NOS) with an IC50 of 10±2 μM for purified neuronal NOS, and poorly inhibits inducible macrophage NOS (IC50>100 μM). Additionally, it is a potent inhibitor of CYP3A4, with a calculated IC50 value of 1.69 μM.
- Potent dopamine D2/D3 receptor agonist
- Permeable to the blood-brain barrier
- Strong inhibitor of brain nitric oxide synthase (NOS)
- Potent inhibitor of CYP3A4
- Shows anti-immobility action in mice (in FST and TST)
- Potentiates the anti-immobility action of MPE
- Decreases static mechanical allodynia (SMA) score in rats
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