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Medchemexpress LLC Broussonin E | 90902-21-9 | 1 ML
SDP

Supplier:  Medchemexpress LLC HYN296310MM/1ML

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Broussonin E is a phenolic compound exhibiting anti-inflammatory activity. It suppresses inflammation by modulating the activation state of macrophages through inhibiting the ERK and p38 MAPK pathways, while enhancing the JAK2-STAT3 signaling pathway. This compound can be utilized for research related to inflammation-related diseases, such as atherosclerosis.

  • Inhibits LPS (lipopolysaccharides)-stimulated phosphorylation of ERK and p38 MAPK at 20 μM for 3 hours.
  • Activates janus kinase (JAK) 2 and signal transducer and activator of transcription (STAT) 3.
  • Suppresses LPS-induced pro-inflammatory production in RAW264.7 cells (0-20 μM, 3 h), including TNF-α, IL-1β, IL-6, COX-2, and iNOS.
  • Enhances the expression of anti-inflammatory mediators such as IL-10, CD206, and arginase-1 (Arg-1) in LPS-stimulated RAW264.7 cells.

Catalog No. 50-004-21226


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