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Medchemexpress LLC BSJ-03-204 (triTFA) | 99.9% | 1174.97 | 25 MG
Supplier: Medchemexpress LLC 25MGHY136250A
BSJ-03-204 triTFA is a PROTAC connected by ligands for Cereblon and CDK. It is a potent and selective Palbociclib-based CDK4/6 dual degrader, with IC50s of 26.9 nM for CDK4/D1 and 10.4 nM for CDK6/D1. This compound does not induce IKZF1/3 degradation and demonstrates anti-cancer activity.
- PROTAC connected by ligands for Cereblon and CDK.
- Potent and selective Palbociclib-based CDK4/6 dual degrader.
- Demonstrates potent anti-proliferative effects on MCL cell lines.
- Induces a G1 arrest.
- Selectively degrades CDK4/6 in WT cells without affecting IKZF1/3 degradation.
- Exhibits anti-cancer activity.
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