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AdipoGen bTubulin b-monoE pAb IN115
Supplier: AdipoGen AG25B0039C050
Polyclonal Antibody. Recognizes the posttranslational modification glutamylation with specific reactivity for the GE*-EF motive. Because the sequence GEF is specific to several beta-tubulin isotypes, the antibody selectively detects mono-glutamylated beta-tubulin. Applications ICC, IHC, IP, WB. Source Rabbit. Polyglutamylation is an evolutionarily conserved protein post-translational modification in which glutamate side chains of variable lengths are formed on the modified protein. The most prominent substrate is tubulin, the building block of microtubules MTs. Polyglutamylation has been found on both, alpha- and beta-tubulin. It is catalyzed by multiple enzymes that belong to the family of tubulin tyrosine-ligase like TTLL enzymes. These TTLLs have substrate alpha- vs beta-tubulin as well as reaction initiation vs elongation specificities.
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