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AdipoGen Bumetanide
SDP

Supplier:  AdipoGen AGCR13543G005

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Chemical. CAS 28395-03-1. Formula C17H20N2O5S. MW 364.4. Bumetanide is a loop diuretic that is clinically used to treat congestive heart failure. Bumetanide also exhibits anxiolytic, neuroprotective and anti-epileptic/anticonvulsant activities. Bumetanide induces hyperpolarization in kidney cells, increasing whole-cell conductance and intracellular Ca2 levels. Bumetanide acts by antagonizing Na/K/2Cl- symporter 1 NKCC1, K/Ca2 co-transporter 2 KCC2 and NKCC2, decreasing fluid secretion and Na/K transport. While NKCC1 is expressed both in the CNS and in systemic organs, NKCC2 is kidney-specific. Bumetanide is a potent and specific inhibitor of Na-K-2Cl cotransporter 1 NKCC1 IC50 = 0.68µM. It is selective for NKCC1 over NKCC2 IC50 = 4µM. It is also an agonist of G protein-coupled receptor 35 GPR35 EC50 = 10µM and can inhibit carbonic anhydrases IX and XII.

Catalog No. 50-256-2313


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