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Medchemexpress LLC Buparlisib Hydrochloride | 1312445-63-8 | C18H22ClF3N6O2 | 1 ML
Supplier: Medchemexpress LLC HY1518010MM/1ML
Buparlisib Hydrochloride (BKM120 Hydrochloride) is a CNS-penetrant pan-class I PI3K inhibitor with IC50 values of 52 nM for p110α, 166 nM for p110β, 116 nM for p110δ, and 262 nM for p110γ. It induces dose- and time-dependent apoptosis in multiple myeloma cell lines.
- Active against class I PI3K's, including common p110α mutants
- Lower potency against class III and IV PI3K's
- Induces dose-dependent growth inhibition in multiple myeloma cell lines
- Oral administration leads to dose-dependent modulation of pAKTSer473 in xenograft tumors
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