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Medchemexpress LLC Buparlisib Hydrochloride | 1312445-63-8 | C18H22ClF3N6O2 | 100 MG
SDP

Catalog No. 5000374179
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Buparlisib Hydrochloride (BKM120 Hydrochloride) is a CNS-penetrant pan-class I PI3K inhibitor. It demonstrates IC50 values of 52 nM for p110α, 166 nM for p110β, 116 nM for p110δ, and 262 nM for p110γ.

  • Exhibits activity between 50-300 nM for class I PI3K's, including common p110α mutants.
  • Shows lower potency against class III and class IV PI3K's such as VPS34, mTOR, DNAPK, and PI4K.
  • Induces multiple myeloma (MM) cell apoptosis in a dose- and time-dependent manner.
  • Causes dose-dependent growth inhibition in various MM cell lines.
  • In A2780 xenograft tumors, oral dosing leads to dose-dependent modulation of pAKTSer473.
  • Inhibition of pAKT (normalized to total AKT) correlates well with both plasma and tumor drug exposure.
  • Significantly reduces tumor burdens and prolongs the survival of tumor-bearing mice.

Catalog No. 50-003-74179 Supplier Medchemexpress LLC Supplier No. HY15180100MG
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Buparlisib Hydrochloride (BKM120 Hydrochloride) is a CNS-penetrant pan-class I PI3K inhibitor. It demonstrates IC50 values of 52 nM for p110α, 166 nM for p110β, 116 nM for p110δ, and 262 nM for p110γ.

  • Exhibits activity between 50-300 nM for class I PI3K's, including common p110α mutants.
  • Shows lower potency against class III and class IV PI3K's such as VPS34, mTOR, DNAPK, and PI4K.
  • Induces multiple myeloma (MM) cell apoptosis in a dose- and time-dependent manner.
  • Causes dose-dependent growth inhibition in various MM cell lines.
  • In A2780 xenograft tumors, oral dosing leads to dose-dependent modulation of pAKTSer473.
  • Inhibition of pAKT (normalized to total AKT) correlates well with both plasma and tumor drug exposure.
  • Significantly reduces tumor burdens and prolongs the survival of tumor-bearing mice.

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