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Cayman Chemical BupIvacaIn-d9 10mg
SDP

Supplier:  Cayman Chemical 1824610 MG

Encompass_Preferred

A multi-kinase inhibitor that inhibits VEGFR2 VEGFR3 VEGFR1 EGFR PDGFRB Tie-2 and FGFR1 (IC50s 40 110 1600 500 1100 2500 and 3600 nM respectively in cell-free assays) also binds to 142 additional kinases in a panel of 442 kinases (Kds 4.6-7900 nM) induces apoptosis and cell cycle arrest at the G0/G1 phase in GEO colon and OVCAR-3 ovarian cancer cells at 1 and 2.5 UM inhibits proliferation of HAK1-B KYN-2 and Huh7 hepatocarcinoma cells and HUVECs (IC50s 10 8.1 9.4 and 7.1 UM respectively) increases survival and decreases tumor angiogenesis and VEGFR2 levels in a D54MG glioblastoma mouse xenograft model at 200 mg/kg reduces tumor growth in a variety of mouse xenograft models at 25-100 mg/kg per day

Catalog No. 50-296-5808


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