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AdipoGen Bupivacaine HCl monohydrate
Supplier: AdipoGen CDXB0326G001
Chemical. CAS 73360-54-0. Formula C18H28N2O . HCl . H2O. MW 288.4. 36.5 . 18.0. Synthetic. Bupivacaine is an amino amide local anesthetic that decreases current amplitude and inhibits whole cell K currents in Ca2-activated K channels and N-type voltage-gated KCNA and KCNC K channels. Bupivacaine also inhibits voltage-gated Na channels and tandem pore domain TASK-2/KCNK-5 K channels. The compound is cytotoxic at high concentrations inducing apoptosis and/or necrosis by interference with the mitochondrial energy transduction. Shown to inhibit aerobic ATP synthesis by i uncoupling of the oxidative phosphorylation OXPHOS and ii inhibition of the complex I of the respiratory. Other mechanisms include inhibition of the carnitine-acylcarnitine translocase or activation of the mitochondrial permeability transition pore MPTP.
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