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Medchemexpress LLC Burixafor (hydrobromide) | 1191450-19-7 | 98.0% | 769.01 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY19867A50MG

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Burixafor hydrobromide is a potent CXCR4 antagonist with a pIC50 of 7.4. It inhibits CXCL12 binding to CXCR4, antagonizes Gαᵢ and β-arrestin2 recruitment, and blocks downstream Gαᵢ-mediated effects on cAMP signal transduction. This compound mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) for research on autologous hematopoietic stem cell transplantation (ASCT).

  • Potent CXCR4 antagonist with a pIC50 of 7.4.
  • Inhibits CXCL12 binding to CXCR4.
  • Antagonizes CXCL12-induced Gαᵢ and β-arrestin2 recruitment.
  • Blocks downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction.
  • Mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC).
  • Useful for research on autologous hematopoietic stem cell transplantation (ASCT).

Catalog No. 50-004-01488


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