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Medchemexpress LLC Burixafor hydrobromide | 1191450-19-7 | 98.0% | 769.01 | 500 MG
SDP

Supplier:  Medchemexpress LLC HY19867A500MG

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Burixafor (TG-0054) hydrobromide is a potent CXCR4 antagonist with a pIC50 of 7.4. It inhibits the binding of CXCL12 to CXCR4, antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2, and blocks the downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction. Burixafor hydrobromide mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood.

  • Can be used for research on autologous hematopoietic stem cell transplantation (ASCT).
  • Potent CXCR4 antagonist.
  • Inhibits CXCL12 binding to CXCR4.
  • Blocks Gαᵢ-mediated inhibitory effect on cAMP signal transduction.
  • Mobilizes CD34+ hematopoietic stem/progenitor cells.

Catalog No. 50-004-01802


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