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Apexbio Technology LLC Busulfan 55-98-1 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A83865.1

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Busulfan is a DNA alkylating agent widely used in biomedical research as an anticancer compound It functions by forming cross-links on guanine bases within DNA leading to DNA damage and subsequent inhibition of cell growth and proliferation In vitro studies reveal that exposure to busulfan (IC50 range approximately 7 5 120 M) promotes cellular senescence in normal human fibroblast cell lines mediated through increased reactive oxygen species (ROS) and sustained activation of MAPK signaling pathways Additionally busulfan is utilized in fertility and reproductive biology research due to its ability to induce apoptosis in male germ cells reducing germ cell populations in experimental mouse models

Catalog No. 50-000-61893


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